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Tendon loading protocols

Most tendon advice is "do eccentrics" with no numbers attached. The trials specify sets, reps, loads, angles and a rule for when to progress. Those parameters are below, each with the trial it came from.

The short version. Heavy slow resistance and staged pain-limited loading both work and both beat or match corticosteroid injection in the long run. Isometric analgesia — the idea that an isometric hold reliably kills tendon pain — has failed replication three times.

What the evidence shows

Findings are grouped by what kind of evidence each one is. That ordering is the point: a sentence from an FDA label and a sentence from a forum are not the same claim, and this page will not present them as though they were.

Clinical trial evidence

Animal or mechanistic only

What the regulator approved

Where a drug on this page has a US label, this is what it was approved for and at what dose. Anything else is off-label — which is not the same as unsafe, but does mean no regulator has reviewed it for that use.

DrugApproved forApproved doseOn-label for this use?
Methylprednisolone acetate (Depo-Medrol) — injected corticosteroid, the only prescription drug appearing in the tendinopathy loading trials retrieved here (used as comparator/adjunct in Kongsgaard 2009 and Couppé 2022)The Indications section retrieved from DailyMed covers Section A, intramuscular administration, and lists allergic states, dermatologic diseases, endocrine disorders, gastrointestinal diseases and haematologic disorders. Tendinopathy, epicoVerbatim from label: 'The initial dosage of parenterally administered DEPO-MEDROL will vary from 4 to 120 mg, depending on the specific disease entity being treated.' No tendon-specific dose was retriNo

What nobody knows

These are the questions the literature does not answer. They are listed because on this subject the gaps are load-bearing: most of what circulates as settled practice sits in one of them.

Sources

Every identifier below was checked to resolve to a real record before publication. Citations retrieved from PubMed and DailyMed.

  1. British Journal of Sports Medicine (2021) — PubMed 33219115 stage 1 consisted of daily isometric exercises (single-leg leg-press or leg-extension, 5 repetitions of 45 s mid-range (60° knee flexion) quadriceps isometric hold at 70% of maximum voluntary contraction)
  2. BMC Musculoskeletal Disorders (2017) — PubMed 28693535 Progression is made by changing from bipedal to unipedal exercises, by progressing from concentric-eccentric to purely eccentric loading, by adding weight in a backpack (in steps of 5 kg when pain did not exceed 5 on a 0–10 numerical rating scale), and finally
  3. The American Journal of Sports Medicine (2007) — PubMed 17307888 The exercise training group (n = 19) was allowed, with the use of a pain-monitoring model, to continue Achilles tendon-loading activity, such as running and jumping, whereas the active rest group (n = 19) had to stop such activities during the first 6 weeks. .
  4. BMJ Open (2020) — PubMed 33444210 There is a predominant use of pain-based criteria, but the utilisation of these criteria is not supported by strong evidence. This review evidences the need for studies that compare the same exercise programme using different progression criteria.
  5. BMC Sports Science, Medicine & Rehabilitation (2024) — PubMed 39390552 Subjects were asked to perform three weekly training sessions, each including three movements (squat, leg press, Bulgarian deep squat). ... Load intensity and repetitions were progressively adjusted throughout the program: starting with 12 repetitions maximum
  6. Scandinavian Journal of Medicine & Science in Sports (2009) — PubMed 19793213 Thirty-nine male patients were randomized to CORT, ECC or HSR for 12 weeks. ... VISA-p and VAS improvements were maintained at follow-up in ECC and HSR but deteriorated in CORT (P<0.05). ... HSR has good short- and long-term clinical effects accompanied by pat
  7. British Journal of Sports Medicine (2015) — PubMed 25979840 6 volleyball players with PT participated. Condition effects were detected with greater pain relief immediately from isometric contractions: isometric contractions reduced SLDS (mean±SD) from 7.0±2.04 to 0.17±0.41, and isotonic contractions reduced SLDS (mean±
  8. Clinical Journal of Sport Medicine (2017) — PubMed 27513733 Two quadriceps resistance protocols were compared; (1) isometric leg extension holds at 60 degrees knee flexion (80% of their maximal voluntary isometric contraction) or (2) isotonic leg extension (at 80% of their 8 repetition maximum) 4 times per week for 4 w
  9. Journal of Science and Medicine in Sport (2020) — PubMed 31735531 There was a significant decrease in pain NRS scores (mean reduction 0.9, NRS 95%CI 0.1-1.7; p = 0.028), and increase in PPTs at the tibialis anterior muscle (mean increase 34 kPa 95%CI 9.5-58.5; p = 0.009) immediately post-exercise. These were not sustained 45
  10. Journal of Science and Medicine in Sport (2020) — PubMed 26707957 There was no significant difference in NRS pain score change (U=29.0, p=0.208, r=0.29) between the isometric group (median (IQR), 2.5 (1-4.5)) and isotonic group (median (IQR), 3.0 (2-6)).
  11. Physical Therapy in Sport (2021) — PubMed 33601254 There was no consistent evidence for EIH following isometric exercise in people with musculoskeletal pain. These findings are different to those reported in asymptomatic populations (where EIH is consistently demonstrated) as well as conditions associated with
  12. The Clinical Journal of Pain (2016) — PubMed 26889612 Participants performed 3 experimental tasks completed in a randomized order on separate days: control (no exercise) and isometric wrist extension (10×15 s) at load 20% below (infrathreshold), and 20% above (suprathreshold) an individual's pain threshold. ... I
  13. Medicine and Science in Sports and Exercise (2020) — PubMed 31425384 No group differences were found for success on global rating of change (29% exercise vs 26% wait-and-see (risk difference, 2.3%; 95% CI, -24.5 to 29.1)), or pain-free grip strength (SMD, -0.33; 95% CI, -0.97 to 0.30). ... With only one of the three primary out
  14. The American Journal of Sports Medicine (2022) — PubMed 35867777 These results suggest that 12 weeks of HSR improved symptoms in both the short and the long term and that a CSI or TN did not amplify this effect. In addition, a CSI seemed to impair patient-reported outcomes compared with HSR alone at long-term follow-up.
  15. BMJ Open (2024) — PubMed 39806585 Only 6 of 19 (32%) did comply with heavy slow resistance training. ... Participants had low compliance with heavy slow resistance training mainly due to pain aggravation, which suggests that this intervention was not suitable for patients with tennis elbow.
  16. Sports (Basel) (2023) — PubMed 36976950 During the ascending phase, (i) biceps brachii excitation was greater with the supinated compared to the pronated [+19(7)%, ES: 2.60] and neutral handgrip [+12(9)%, ES: 1.24], (ii) the brachioradialis showed greater excitation with the supinated compared to th
  17. Journal of Electromyography and Kinesiology (2017) — PubMed 28011412 The concentric phases of each pull-up variation resulted in significantly greater EMGARV of the brachioradialis, biceps brachii, and pectoralis major in comparison to the eccentric phases (P=<0.01). Results indicate that EMGPEAK and EMGARV of the shoulder-arm-
  18. Journal of Strength and Conditioning Research (2010) — PubMed 20543740 Repeated-measures analysis of variance for each muscle revealed that a pronated grip elicited greater LD activity than a supinated grip (p < 0.05), but had no influence of grip type on the MT and BB muscles.
  19. Journal of Strength and Conditioning Research (2021) — PubMed 30694963 When using the FG, 1RM strength was significantly decreased for each exercise, and the maximal number of pull-ups completed was significantly lower. Electromyography muscle activity was significantly increased in the forearm and shoulder muscles, but significa
  20. Sports Biomechanics (2021) — PubMed 31198105 There were no differences between the WS and WOS conditions in the number of repetitions per set, total repetitions and latissimus dorsi muscle activation. In conclusion, the findings of this study demonstrate that the use of lifting straps in the lat pull-dow
  21. Shoulder & Elbow (2014) — PubMed 27582910 Distal biceps and triceps tendinopathies are very rare and there is limited evidence published. Sequelae of tendinopathy include tendon rupture and so it is vital to manage these tendinopathies appropriately in order to minimise this significant complication.
  22. Methylprednisolone acetate (Depo-Medrol) — injected corticosteroid, the only prescription drug appearing in the tendinopathy loading trials retrieved here (used as comparator/adjunct in Kongsgaard 2009 and Couppé 2022) — US Prescribing Information (DailyMed) Approved indication: The Indications section retrieved from DailyMed covers Section A, intramuscular administration, and lists allergic states, dermatologic diseases, endocrine disorders, gastrointestinal diseases and hae

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