Ipamorelin half-life and steady state
2 h modelled half-life, peaking 42 min after a dose. What that means for how long it lasts, how much it builds up, and when bloodwork is worth drawing.
- Also known as
- Ipa, Selective GHRP
- Class
- Peptides
- Modelled half-life
- 2 h
- Time to peak
- 42 min
- Formulation
- Aqueous (reconstituted powder)
- Cleared per dosing interval
- 100% gone, 0% still present after 24 h
- Time to steady state
- ~10 h (about five half-lives)
- Accumulation at that cadence
- 1× — effectively none; each dose clears before the next
- Peak-to-trough at steady state
- Not meaningful — the level returns to zero between doses, so there is no trough to divide into a peak
- Regulatory status
- Research compound — no FDA approval. Not for human use label.
- Monitoring panel
- IGF-1 at baseline and every 3 months. Fasting glucose.
- Before mixing
- Sealed powder tolerates room temperature in transit, but keep it refrigerated at 2–8 °C (36–46 °F) for anything beyond a few weeks, or frozen for months. Keep it dark — the carton it shipped in is doing a job.
- After mixing
- Once reconstituted with bacteriostatic water: refrigerate at 2–8 °C and use within about 28 days. The benzyl alcohol in bacteriostatic water is what buys that window — plain sterile water has no preservative, so a vial mixed with it should be treated as one sitting only. Kits are usually ten vials: only the one you mixed is on that 28-day clock — the sealed ones keep their own, much longer shelf life, so store them as powder, not as solution.
- What ruins it
- Do not freeze a reconstituted vial. Repeated freeze–thaw is one of the more reliable ways to degrade a peptide.
- Handling caveat
- General handling practice for this formulation. Your supplier’s own insert or COA overrides anything here.
Ipamorelin's two-hour half-life is long enough to be measured and far too short to accumulate on any daily schedule — twelve half-lives fit inside a day. Like CJC-1295 without DAC, it is dosed for a pulse rather than for a level, and for the same reason: growth hormone secretion is pulsatile, and a secretagogue that persisted would blunt the pattern it is trying to amplify.
What distinguishes ipamorelin from the other growth hormone secretagogues is selectivity rather than duration. GHRP-2 and hexarelin act at the same ghrelin receptor but also drive cortisol and prolactin; ipamorelin is described in the literature as doing very little of that, which is the entire basis for preferring it. That is a receptor-selectivity claim, not a pharmacokinetic one — the curve on this page would look much the same for a less selective peptide.
Because it works through a different receptor from a GHRH analogue, the two are complementary rather than redundant, which is what the CJC-1295 pairing in the app's dosing rows is about. Two short-acting compounds given together produce one larger pulse and then both clear, so the timing constraints are the same for both: fasted, and away from carbohydrate, because insulin suppresses growth hormone release. Ipamorelin is a research compound with no approval for human use; the monitoring the app records for it — IGF-1 and fasting glucose — reflects that a sustained rise in growth hormone signalling has metabolic consequences worth watching.
One dose
pkCurve function — a
one-compartment absorption-and-elimination model with the absorption rate fitted so the
peak lands at the published time to peak.Dosed once daily
Charted at once daily because that is the once-daily pre-bed schedule in the app's own dosing rows. It is what the numbers below are indexed to, not a recommendation about frequency — that is a prescribing decision.
The arithmetic behind those numbers
fraction left after one interval = 2^(−12.00) = 0.000
accumulation ratio = 1 ÷ (1 − 0.000) = 1
time to steady state ≈ 5 × half-life = 10 h
peak-to-trough = not meaningful; the trough is 0.0003 of a single dose's peak, i.e. cleared
The accumulation ratio is a closed form; the peak-to-trough figure is not. The generator adds up enough repeated curves for the total to stop changing, then reads the highest and lowest points of the last interval — which is what steady state means in practice. The vertical axis is relative, not a concentration: the shape and the ratios carry across people, the absolute levels do not.
Interaction rules that name Ipamorelin
From the app's own interaction data. Not exhaustive, and not a safety clearance — a combination that is not listed is one nobody has documented here, which is not the same as one that is fine. The full combination checker has the rest.
Excellent GHRH + GHRP Synergistic Pairing
Tesamorelin (GHRH analogue) and Ipamorelin (GHRP) work synergistically to produce larger GH pulses than either alone — the GHRH primes the somatotrophs and the GHRP amplifies the pulse. This is the FDA-validated compound type pairing with the most evidence.
What to watch: IGF-1 every 3 months, fasting glucose, HbA1c.
Gold Standard GH Secretagogue Pairing
CJC-1295 (GHRH analogue) and Ipamorelin (selective GHRP) are the gold standard GH secretagogue combination. CJC-1295 primes pituitary somatotrophs while Ipamorelin triggers GH release with minimal cortisol or prolactin elevation. Always pair these — neither is as effective alone.
What to watch: IGF-1 every 3 months. Fasting glucose. No prolactin monitoring needed with Ipamorelin.
The dosing rows this cadence came from
Off-label or community practice Reproduced from the app's entry so you can see what the chart above is indexed to. Which row applies to a particular person, if any, is a clinical decision this page does not make.
| Label | Amount | Route and frequency |
|---|---|---|
| Starting | 100-150mcg | Once daily 30 min before bed fasted |
| Optimized | 200-300mcg | Twice daily fasted AM and pre-bed |
When to draw bloodwork
The panel the app records for Ipamorelin is: IGF-1 at baseline and every 3 months. Fasting glucose.. The pharmacokinetic point is the timing rather than the list: after any change, a level takes about 10 h to settle, so a panel drawn sooner measures something still moving. And because this compound clears completely between doses, a serum level says only what the last few hours did — which is why the marker worth following here is a downstream one measured over weeks, not the compound itself. Whether a result means anything is a question for the clinician who ordered it, read against the reference range your own lab printed. The lab-marker pages cover what the individual analytes measure.
Related: the interactive half-life calculator to try other cadences.
The app draws this curve from the doses you actually logged — your dates, your cadence — and projects seven days forward from the last one.
Save this dose to your log